Protein Modification Reagents

Medchemexpress LLC Mal-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-52-8 | 1559.62 | C74H98N10O27 | 10 MG

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Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a cleavable antibody-drug conjugate (ADC) drug-linker conjugate that combines a Mal-PEG4-VC-PAB cleavable linker with the cytotoxic payload DMEA-PNU-159682 for use in ADC research and drug-conjugate development.

• Cleavable ADC drug-linker conjugate suitable for antibody-drug conjugate synthesis.
• Contains a maleimide functional group for thiol conjugation.
• High molecular weight for payload delivery and characterization.
• Supplied in small research pack sizes for controlled studies.
• Store solid at -20°C, protect from light, and keep under inert gas; follow solvent storage recommendations for solutions.

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Medchemexpress LLC Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]- | 663921-15-1 | MFCD11041129 | 99.9% | 265.30 g/mol | C11H23NO6 | 100 MG

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NH2-PEG4-CH2CH2COOH is a cleavable four-unit polyethylene glycol (PEG) linker with an N-terminal amine and a terminal propanoic acid, designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis.

• Cleavable 4-unit PEG linker.
• Amine functional group for conjugation.
• Terminal carboxylic acid for coupling reactions.
• High purity (99.9%).
• Molecular weight 265.30 g/mol.
• Soluble in DMSO.
• Available as a 100 MG pack.

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Cayman Chemical BIOnT PROTAC FRGmnt lbrar 10mg

Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3

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Medchemexpress LLC Mal-PEG4-C2-NH2 TFA | 2512227-13-1 | 430.37 | 250 MG

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Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.

• PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• Contains two different ligands connected by a linker
• Targets E3 ubiquitin ligase and target proteins
• Exploits intracellular ubiquitin-proteasome system
• Selectively degrades target proteins

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Medchemexpress LLC m-PEG4-Hydrazide | 1449390-68-4 | >98% | C10H22N2O5 | 25 MG

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m-PEG4-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• PROTAC linker
• PEG-based

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Medchemexpress LLC HO-PEG24-OH | 2243942-52-9 | 99.9% | C48H98O25 | 50 MG

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HO-PEG24-OH is a high-purity, polyethylene glycol (PEG)-based PROTAC linker with a purity of 99.89%. This linker is specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs), providing a versatile building block for targeted protein degradation research.

• Peg-based linker
• Designed for PROTAC synthesis
• High purity for research applications
• Supports targeted protein degradation studies

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eMolecules​ 581065-94-3 | Tos-PEG5 t-butyl ester | Broadpharm | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352

Tos-PEG5 t-butyl ester | Broadpharm | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352

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eMolecules​ 9-(Azide-PEG9-ethylcarbamoyl)nonanoic t-butyl ester | Broadpharm |722.918 | C34H66N4O12 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 490840938

9-(Azide-PEG9-ethylcarbamoyl)nonanoic t-butyl ester | Broadpharm |722.918 | C34H66N4O12 | 0.000 | CC(C)(C)OC(=O)CCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 50mg | 490840938

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Medchemexpress LLC Dbco-conh-s-s-nhs ester | 1435934-53-4 | MFCD22380758 | 99.2% | 565.66 g/mol | C28H27N3O6S2 | 5 MG

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DBCO-CONH-S-S-NHS ester is a cleavable disulfide-containing ADC linker that combines a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with an N-hydroxysuccinimide (NHS) activated ester for conjugation to amines.

• Provides a cleavable disulfide spacer for controlled payload release.
• Enables copper-free click chemistry via DBCO for bioorthogonal conjugation.
• Contains an NHS-activated ester for efficient amine coupling.
• High reported purity supports sensitive bioconjugation workflows.
• Soluble in DMSO at high concentrations for easy handling and stock preparation.
• Stable when stored protected from light and under inert atmosphere at low temperatures.

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eMolecules​ 1402080-11-8 | Fmoc-PEG5-NHS ester | Broadpharm | MFCD28976702 | 628.675 | C32H40N2O11 | 98.000 | O=C(CCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12)ON1C(=O)CCC1=O | 1g | 343283761

Fmoc-PEG5-NHS ester | Broadpharm | 1402080-11-8 | MFCD28976702 | 628.675 | C32H40N2O11 | 98.000 | O=C(CCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12)ON1C(=O)CCC1=O | 1g | 343283761

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Medchemexpress LLC TCO-PEG8-NHS ester | 2353409-95-5 | 95.0% | C32H54N2O14 | 25 MG

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TCO-PEG8-NHS ester is a PEG-based PROTAC linker. It can be used in the synthesis of PROTACs, which are compounds containing two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for a target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• Contains two different ligands connected by a linker
• One ligand for an E3 ubiquitin ligase
• Other ligand for a target protein
• Exploits the intracellular ubiquitin-proteasome system
• Selectively degrades target proteins

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Medchemexpress LLC Amine-PEG-thiol (MW 2000) | 93.0% | 100 MG

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Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• Molecular weight: 2000 (average)
• Appearance: solid
• Color: white to off-white
• Shipping: room temperature in continental US; may vary elsewhere
• Storage: powder -20°C 3 years; in solvent -80°C 6 months, -20°C 1 month
• Solubility: in DMSO: 50 mg/mL (need ultrasonic; hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
• For research use only

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Medchemexpress LLC M-PEG-C1-DSPE sodium (MW 1000) | 1000 | 500 MG

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M-PEG-C1-DSPE sodium (MW 1000) is a PEG lipid and a structural analog of m-PEG-DSPE sodium (MW 1000) (HY-W440922). It can improve the delivery efficiency and tissue specificity of poorly soluble drugs.

• Enhances delivery efficiency of poorly soluble drugs.
• Enhances tissue specificity of poorly soluble drugs.
• Suitable for use in drug delivery research.

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eMolecules​ DOPE-PEG-Cy5, MW 2,000 | Broadpharm |1295.779 | C76H119N4O11P | 98.000 | CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851

DOPE-PEG-Cy5, MW 2,000 | Broadpharm |1295.779 | C76H119N4O11P | 98.000 | CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851

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Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.2% | C47H61N5O9S | 50 MG

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Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its DBCO group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.

• PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• Click chemistry reagent
• Contains a DBCO group
• Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules

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